Xyosted testosterone enanthate New formulation approval Testosterone enanthate Usually, puberty in males begins between the ages of 9 and 14 years and starts with the enlargement of the testes. The FDA has only approved testosterone for hypogonadism in cases where it is the result of an underlying medical condition rather than aging. This suggests doctors are prescribing testosterone to people who may not need it or do not have low enough testosterone to indicate a medical condition. The authors of the review emphasize that it is still unclear if doing this is beneficial or safe. Long-term TRT can suppress the hypothalamic-pituitary-gonadal (HPG) axis, reducing endogenous testosterone and spermatogenesis. This may result in testicular atrophy and infertility, particularly in younger men. Post-cycle therapy (PCT) or human chorionic gonadotropin (hCG) protocols may be used to help restore natural hormone production (Turek, 2022). These injections do not cure the underlying condition, but they may help alleviate some of the symptoms. Testosterone cypionate and enanthate are prescription drugs taken to treat symptoms of hypogonadism in males. Testosterone enanthate is also approved for use in females for treating mammary gland cancer. Tell your health care provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them know if testosterone is right for you. Misusing testosterone can lead to serious side effects, such as heart problems or mental health problems. Misuse means using a medicine in a way other than how it was prescribed or using too much. In addition, Almukhtar et al. reported that the kidney tissues of four bodybuilders who used more than 400 mg of testosterone propionate in a week showed tubular necrosis and increased kidney inflammation (13). Apoptosis, an influential factor in developing kidney fibrosis, can be triggered by various inflammatory cytokines (14). Androgens also play an essential role in the induction of apoptosis. For example, androgens can induce kidney cell apoptosis by inducing a caspase-dependent apoptotic pathway (15). Also, testosterone can induce the production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), leading to renal inflammation and CKD progression (16). Testosterone replacement therapy (TRT) is a medical intervention designed to supplement or restore the body’s natural testosterone levels. Dr. Gulzar has been working in medical communications, writing medical and clinical research for patients and health professionals in the United Kingdom. Testosterone enanthate injection contains testosterone, a Schedule III controlled substance in the Controlled Substances Act. Testosterone is a controlled substance because it can be misused or lead to dependence. Store testosterone in a safe place to protect it from theft. Certain testosterone injectable products may also be used as part of breast cancer treatment. Testosterone can affect bone growth in boys who are treated for delayed puberty. Bone development may need to be checked with x-rays every 6 months during treatment. A program has been set up to limit the use of testosterone undecanoate injection (Aveed) and to inform people about